Search results for "Blocking effect"

showing 3 items of 3 documents

Biomolecular conjugation inside synthetic polymer nanopores via glycoprotein-lectin interactions

2011

We demonstrate the supramolecular bioconjugation of concanavalin A (Con A) protein with glycoenzyme horseradish peroxidase (HRP) inside single nanopores, fabricated in heavy ion tracked polymer membranes. Firstly, the HRP-enzyme was covalently immobilized on the inner wall of the pores using carbodiimide coupling chemistry. The immobilized HRP-enzyme molecules bear sugar (mannose) groups available for the binding of Con A protein. Secondly, the bioconjugation of Con A on the pore wall was achieved through its biospecific interactions with the mannose residues of the HRP enzyme. The immobilization of biomolecules inside the nanopore leads to the reduction of the available area for ionic tran…

NanometresSynthetic membraneTransport equationNanoporesInformation processingRectification propertiesCylinders (shapes)Materials TestingConcanavalin AGeneral Materials ScienceFunctional polymersConical nanoporeschemistry.chemical_classificationChemistryBlocking effectElectric rectifiersComputer simulationEnzymesData processingNanoporeEnzyme moleculesFunctional polymersMolecular imprintingPorosityBio-molecularInner wallsMolecular imprintingSupramolecular chemistryNanotechnologyHorseradish peroxidaseIonic transportsNanocapsulesBio-conjugationMoleculeParticle SizeAqueous solutionsGlycoproteinsBiomoleculesBioconjugationBiomoleculeNanostructuresModel simulationChemical engineeringModels ChemicalPolymer membraneConductance stateFISICA APLICADABiospecific interactionSynthetic polymersSugarsSupramolecular chemistryPore wallCarbodiimide-coupling chemistry
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A comparison of the antihypertensive action of propranolol and the optical isomers of N-isopropyl-p-nitrophenylethanolamine (INPEA)

1969

In hypertensive patients, the effect of propranolol and of the optical isomers of N-isopropyl-p-nitrophenylethanolamine (INPEA) on blood pressure was studied. Single oral doses of 40 mg propranolol, 700 mg (−)-INPEA and 700 mg (+)-INPEA decreased supine systolic as well as standing systolic and diastolic blood pressure. Single intravenous doses of 75 mg (−)-INPEA and 75 mg (+)-INPEA lowered supine systolic and diastolic blood pressure. The antihypertensive action of the beta adrenergic blocking levorotatory isomer of INPEA and of the dextrorotatory isomer, which is devoid of beta adrenergic blocking activity, did not differ. It is concluded from these results that the antihypertensive actio…

Pharmacologymedicine.medical_specialtyBeta-adrenergic blocking agentSupine positionAdrenergic receptorChemistryBlocking effectGeneral MedicinePropranololLevorotatoryEndocrinologyBlood pressureInternal medicinemedicinePharmacology (medical)Isopropylmedicine.drugPharmacologia Clinica
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Rain on building façades

2006

Rain is one of the main causes of moisture damage to the building envelope, leading to problems such as rain penetration, frost and salt damage, discoloration by leaching, soiling by differential washing, etc. The potential of deterioration due to rain depends on the façade material, the junction of building envelope components, the overall geometry of the building, but also the presence or absence of modulation on the façade. In this paper, Computational fluid dynamics (CFD) simulations are used to analyze these effects and illustrated with examples taken in Sicily. It is firstly shown that buildings protect themselves from driving rain due to the wind blocking effect, but that façade open…

moisture damage building envelope rain penetration frost and salt damage façade material wind blocking effect
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